1 2 3 4 5
For your own scientific reference, we encourage you to access the following links pertaining to the citations above: Publication from PLOS Pathogens “Inactivation of Prions and Amyloid Seeds with Hypochlorous Acid”  http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005914 Publication from The Journal of Clinical Investigation. “Topical hypochlorite ameliorates NF-kB-mediated skin diseases in mice”  www.jci.org/articles/view/70895 Publication from Puget Sound Blood Center and UW Medical School. “Oxidative modification of von Willebrand factor by neutrophil oxidants inhibits its cleavage by ADAMTS13”  www.ncbi.nlm.nih.gov/pmc/articles/PMC2810979/ Publication in the US National Library of Medicine, National Institutes of Health. “Fibrin Clot Structure and Mechanics Associated with Specific Oxidation of Methionine Residues in Fibrinogen”  www.ncbi.nlm.nih.gov/pmc/articles/PMC3514520/ Publication from The Journal of Immunology. “Hypochlorous Acid: A Natural Adjuvant That Facilitates Antigen Processing, Cross- Priming, and the Induction of Adaptive Immunity” www.jimmunol.org/content/184/2/824.full?sid=596e6dd4-43ca-47e9-98f5-770ee2b1f3eb Publication from Medscape Multispecialty. “Hypochlorous Acid: An Ideal Wound Care Agent With Powerful Microbicidal, Antibiofilm, and Wound Healing Potency”  www.medscape.com/viewarticle/838158
As   an   antimicrobial,   antiviral   and   antifungal   that   is   safe   for   all   mucosal   contact,   HOCl   hurries   healing, works   to   mitigate   scarring,   to   clear   a   myriad   of   skin   issues   and   conditions,   can   be   misted   to   permeate small   crevices   for   effective   odor   control   and   sanitation,   and   a   review   of   HOCl   attributes   will   show   the following citations:     reduces skin aging  2     makes blood clot in wounds  3     causes fibrinogen oxidation, leads to firmer clots and longer clot lysis period  4     stimulates immunity to germs  5     produces powerful local stimulants of wound healing and germ killing  5     makes new skin cells grow over wounds and reorganizes scar fibers  6     leads to long lasting local effects in the body  6 While   the   100   year   history   of   Hypochlorous   Acid   (HOCl)   has   provided   indisputable   evidence   of   its efficacy   in   healing   and   use   in   disinfection,   and   over   500   peer-reviewed,   published   papers   universally document   significant   beneficial   results,   the   widespread   use   of   HOCl   has   remained   fairly   stagnant, and   the   primary   limiting   factor   to   broad   adoption   of   this   important   technology,   historically,   has   been due to its lack of stability. With   that   knowledge,   and   the   bottom-line   mission   to   fundamentally   change   the   discussion   of   health, healing    and    disinfection    around    the    world,    BRIOTECH    dove    into    all    things    HOCl    —    science, technology,   equipment,   properties   and   production.   Through   eight   years   of   research,   BRIOTECH   has brought    HOCl    technology    to    the    forefront    through    trade-secret    developments    in    properties    and production   which   have   been   documented   and   published   as   scientific   breakthroughs   in   both   efficacy and stability.

G O I N G B A C K 1 0 0 Y E A R S…

W H A T I S H O C L ?

BRIOTECH’S SCIENTIFIC  BREAKTHROUGH
BRIOTECH, ITS LOGOS, LANGUAGE, AND IMAGES ARE TRADEMARKS AND/OR THE COPYRIGHT PROPERTY OF BRIOTECH, INC. AND/OR ITS AFFILIATES. © 2013-2018
BRIOTECH, ITS LOGOS, LANGUAGE, AND IMAGES ARE TRADEMARKS AND/OR THE COPYRIGHT PROPERTY OF BRIOTECH, INC. AND/OR ITS AFFILIATES. © 2013-2018
FDA FACILITY REG #3012261723 | EPA #93108
Harmful   pathogens,   such   as   bacteria,   spores   and   viruses,   can   be   found all   around   us   —   in   the   air,   on   food,   plants,   animals,   and   on   inanimate surfaces.   The   human   body   uses   innate,   non-specific   mechanisms   as   the first    line    of    defense    against    pathogens,    infection    and    injury.    The    skin itself,     and     mucous     secretions     at     epithelial     membranes,     are     both important   elements   of   the   innate   resistance   response.   But   when   these are   breached,   HOCl   is   immediately   generated   by   the   body   in   response as the key chemical component of innate immunity. A    cascade    of    benefits    comes    about    with    this    HOCl    production.    The mechanism     of     HOCl     production     from     salt     in     the     body     involves intracellular     enzymes,     but     outside     the     body     the     process     can     be mimicked by using controlled application of electrical energy instead —  an electrochemical activation (ECA) process.  
Phagocytosis    was    discovered    by microbiologist   Élie   Metchnikoff   in the    1880s,    who    won    the    Nobel Prize for his discovery.

H O C L : R E A L S C I E N C E I N T H E H U M A N B O D Y

The    following    search    suggestions    will    provide    you    with    a    myriad    of    resource    materials,    such    as    medical publications,   case   studies   and   news   articles   relative   to   hypochlorous   acid   (HOCl).   We   have   systematically researched   this   material   over   the   years   to   realize   the   facts   and   further   our   knowledge   and   understanding   of this   wonderful   product.   As   a   result   of   our   research,   we   are   encouraged   by   the   affirmation   of   the   scientific community as to the positive effects of HOCl   on humans, animals, and the environment.
“Topical Hypochlorite Ameliorates NF-kB-Mediated Skin Diseases in Mice” www.jci.org/articles/view/70895 “Oxidative Modification of von Willebrand Factor by Neutrophil Oxidants Inhibits its Cleavage by ADAMTS13” www.ncbi.nlm.nih.gov/pmc/articles/PMC2810979 “Fibrin Clot Structure and Mechanics Associated with Specific Oxidation of Methionine Residues in Fibrinogen” www.ncbi.nlm.nih.gov/pmc/articles/PMC3514520 “Hypochlorous Acid: A Natural Adjuvant That Facilitates Antigen Processing, Cross-Priming, and the Induction of Adaptive Immunity”  www.jimmunol.org/content/184/2/824.full “Hypochlorous Acid: An Ideal Wound Care Agent With Powerful Microbicidal, Antibiofilm, and Wound Healing Potency” www.medscape.com/viewarticle/838158 “The National Necrotizing Fasciitis Foundation Says Current Standard of Care for Flesh-eating Bacteria is ‘Tragically Inadequate’” www.marketwatch.com/story/the-national-necrotizing-fasciitis-foundation “Activated and Electrolyzed Water: A Brief Review of a New Generation of Cleaners and Sanitizing Agents.” www.foodsafetymagazine.com/magazine-archive1/augustseptember-2010 “Stabilized Hypochlorous Acid: Its Role In Decreasing Tissue Bacterial Bioburden” www.citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.9102 “The Inhibition of Bacterial Growth By Hypochlorous Acid. Possible role in the bactericidal activity of phagocytes.” www.ncbi.nlm.nih.gov/pmc/articles/PMC1135139 “Hypochlorous Acid as a Potential Wound Care Agent” www.ncbi.nlm.nih.gov/pmc/articles/PMC1853323 “Efficacy of Electrolyzed Oxidizing Water for Inactivating Escherichia coli O157:H7, Salmonella Enteritidis, and Listeria Monocytogenes” www.ncbi.nlm.nih.gov/pubmed/10473453 “Experimental Observations on the Antiseptic Action of Hypochlorous Acid and Its Application to Wound Treatment” www.ncbi.nlm.nih.gov/pmc/articles/PMC2302602

S C I E N T I F I C R E S E A R C H P U B L I C A T I O N S

The   BRIOTECH   vision   has   always   been   about   what   HOCl   can   do   for   the   good   of   man,   in   medicine,   and healthcare,   and   we’re   excited   to   lead   the   hypochlorous   acid   industry   with   game-changing   therapeutic and disinfection technologies. 1

HOW B R I O T E C H’S H O C L I S U N I Q U E

Furthering    the    development    of    Electro-Chemical    Activated    (ECA)    Technology,    BRIOTECH    has scientifically   engineered   a   process   to   mass-produce   hypochlorous   ( hī-′pə-klôr-′əs )   products   that   are highly-effective.   The   ECA   formulations   that   BRIOTECH   produces   are   superior   in   purity   and   have been   proven   to   maintain   electrical   efficacy   beyond   two   years.   In   this   stable   form,   these   electrically active   HOCl   solutions   maintain   efficacy   and   power   to   influence   many   biochemical   events   in   human and animal tissues, and in microbes. Under   stringent   quality-control   procedures,   we   use   water   (H2O)   and   salt   (NaCl)   to   create   a   specific brine    solution,    and    then    pass    the    brine    through    a    proprietary,    electrolytic    chamber.    The    finished hypochlorous   acid   is   a   weak   acid;   it   is   a   very   different   structure   from   the   strong   acid   generated   in   the stomach—hydrochloric acid—that works to start digestive processes there.  Throughout     the     world,     commercial     industries     such     as     hospitality,     janitorial,     food     and     water processing,     agricultural,     animal     husbandry,     and     health     and     public     safety     have     adopted     ECA Technology for use, eliminating the need for harmful, toxic chemicals.

H O W W E M A K E H O C L

    Only BRIO HOCL TM  has been proven to eliminate the world’s most dangerous and hardiest pathogen     More closely than any other HOCl on the market, BRIOTECH mimics what is produced inside the body     Our formulations contain no active components other than pure HOCl (unlike other HOCl producers)     Our HOCl is unmatched in safety, efficacy, and stability     BRIOTECH formulations are HOCl in its purest form     Our purity allows us to continually achieve ground-breaking results     BRIOTECH’s scaling capacity sets the industry precedent for production     BRIOTECH manufactures HOCl in an FDA-registered, GMP-compliant facility     A commitment of eight years in scientific research and testing in HOCl properties and production
    HOCl is a natural part of our internal defense system     Produced by white blood cells     Works to fight infection, control responses to injury, and enhance healing     Part of the healthy response to injury and recover     HOCl consistently shows no adverse effects     Will not irritate or aggravate tissue damage at wound sites     There is no bubbling or tingling sensation, unlike many other topically applied solutions     Soothing, steady control over the healing process that quickly become evident     Safe for use on humans and animals
When    produced    outside    the    body,    HOCl    is    an    electrolyzed,    antimicrobial,    biocide    solution    that inactivates pathogens such as bacteria, viruses, spores, and fungi.
HOCl O H Cl 6
BRIOTECH’S SCIENTIFIC BREAKTHROUGH
     For your own scientific reference, we encourage you to access the       following links pertaining to the citations above:             Publication from PLOS Pathogens “Inactivation of Prions and Amyloid     Seeds with Hypochlorous Acid”     http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005914             Publication from The Journal of Clinical Investigation. “Topical          hypochlorite ameliorates NF-kB-mediated skin diseases in mice”         www.jci.org/articles/view/70895             Publication from Puget Sound Blood Center and UW Medical School.       “Oxidative modification of von Willebrand factor by neutrophil        oxidants inhibits its cleavage by ADAMTS13”          www.ncbi.nlm.nih.gov/pmc/articles/PMC2810979/             Publication in the US National Library of Medicine, National        Institutes of Health. “Fibrin Clot Structure and Mechanics Associated        with Specific Oxidation of Methionine Residues in Fibrinogen”        www.ncbi.nlm.nih.gov/pmc/articles/PMC3514520/             Publication from The Journal of Immunology. “Hypochlorous Acid: A        Natural Adjuvant That Facilitates Antigen Processing, Cross-Priming,        and the Induction of Adaptive Immunity”      www.jimmunol.org/content/184/2/824.full?sid=596e6dd4-43ca-47e9-98f5             Publication from Medscape Multispecialty. “Hypochlorous Acid: An        Ideal Wound Care Agent With Powerful Microbicidal, Antibiofilm,               and Wound Healing Potency”         www.medscape.com/viewarticle/838158
reduces skin aging 2 makes blood clot in wounds 3 causes fibrinogen oxidation, leads to firmer clots and longer clot lysis period 4   stimulates immunity to germs 5 produces powerful local stimulants of wound healing and germ killing 5 makes new skin cells grow over wounds and reorganizes scar fibers 6 leads to long lasting local effects in the body 6 While   the   100   year   history   of   Hypochlorous   Acid   (HOCl)   has provided   indisputable   evidence   of   its   efficacy   in   healing   and use   in   disinfection,   and   over   500   peer-reviewed,   published papers    universally    document    significant    beneficial    results, the   widespread   use   of   HOCl   has   remained   fairly   stagnant, and    the    primary    limiting    factor    to    broad    adoption    of    this important   technology,   historically,   has   been   due   to   its   lack   of stability. With     the     bottom-line     mission     to     fundamentally     change                                     the    discussion    of    health,    healing    and    disinfection    around                  the    world,    BRIOTECH    has    invested    into    all    things    HOCl— science,   technology,   equipment,   properties   and   production— and   in   eight   years   of   research,   BRIOTECH   has   brought   HOCl technology   to   the   forefront   through   documented   proprietary developments    and    published    as    scientific    breakthroughs    in both efficacy and stability.

GOING BACK 100 YEARS…

WHAT IS HOCL?

BRIOTECH, ITS LOGOS, LANGUAGE, AND IMAGES ARE TRADEMARKS AND/OR THE COPYRIGHT PROPERTY OF BRIOTECH, INC. AND/OR ITS AFFILIATES. © 2013-2018
BRIOTECH, ITS LOGOS, LANGUAGE & IMAGES ARE TRADEMARKS & COPYRIGHT PROPERTY OF BRIOTECH, INC. & ITS AFFILIATES. © 2013-2018
FDA FACILITY REG #3012261723 | EPA #93108
Harmful      pathogens,      such      as      bacteria, spores   and   viruses,   can   be   found   all   around us—in   the   air,   on   food,   plants,   animals,   and on    inanimate    surfaces.    The    human    body uses     innate,     non-specific     mechanisms     as the   first   line   of   defense   against   pathogens, infection    and    injury.    The    skin    itself,    and mucous   secretions   at   epithelial   membranes, are   both   important   elements   of   the   innate resistance   response.   But   when   these   are   breached,   HOCl   is immediately   generated   by   the   body   in   response   as   the   key chemical component of innate immunity. A      cascade      of      benefits      comes      about      with      this      HOCl production.   The   mechanism   of   HOCl   production   from   salt   in the   body   involves   intracellular   enzymes,   but   outside   the   body the   process   can   be   mimicked   by   using   controlled   application of    electrical    energy    instead—an    electrochemical    activation (ECA) process.  
Phagocytosis was discovered by microbiologist Élie Metchnikoff in the 1880s, who won the Nobel Prize for his discovery.

HOCL: REAL SCIENCE IN THE HUMAN BODY

As   an   antimicrobial,   antiviral   and   antifungal   that   is   safe   for   all mucosal    contact,    HOCl    hurries    healing,    works    to    mitigate scarring,   to   clear   a   myriad   of   skin   issues   and   conditions,   can be    misted    to    permeate    small    crevices    for    effective    odor control   and   sanitation,   and   a   review   of   HOCl   attributes   will show the following citations:
“Topical Hypochlorite Ameliorates NF-kB-Mediated Skin Diseases in Mice” www.jci.org/articles/view/70895 “Oxidative Modification of von Willebrand Factor by Neutrophil Oxidants Inhibits its Cleavage by ADAMTS13” www.ncbi.nlm.nih.gov/pmc/articles/PMC2810979/ “Fibrin Clot Structure and Mechanics Associated with Specific Oxidation of Methionine Residues in Fibrinogen” www.ncbi.nlm.nih.gov/pmc/articles/PMC3514520/ “Hypochlorous Acid: A Natural Adjuvant That Facilitates Antigen Processing, Cross-Priming, and the Induction of Adaptive Immunity” www.jimmunol.org/content/184/2/824.full?sid=596e6dd4-43ca- 47e9-98f5-770ee2b1f3eb “Hypochlorous Acid: An Ideal Wound Care Agent With Powerful Microbicidal, Antibiofilm, and Wound Healing Potency” www.medscape.com/viewarticle/838158 “The National Necrotizing Fasciitis Foundation Says  Current Standard of Care for Flesh-eating Bacteria is ‘Tragically Inadequate’” www.marketwatch.com/story/the-national-necrotizing-fasciitis-foundation “Activated and Electrolyzed Water: A Brief Review of a New Generation of Cleaners and Sanitizing Agents.” www.foodsafetymagazine.com/magazine-archive1/augustseptember-2010 “Stabilized Hypochlorous Acid: Its Role In Decreasing Tissue Bacterial Bioburden” www.citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.9102 “The Inhibition of Bacterial Growth By Hypochlorous Acid. Possible role in the bactericidal activity of phagocytes.” www.ncbi.nlm.nih.gov/pmc/articles/PMC1135139/ “Hypochlorous Acid as a Potential Wound Care Agent” www.ncbi.nlm.nih.gov/pmc/articles/PMC1853323/ “Efficacy of Electrolyzed Oxidizing Water for Inactivating Escherichia coli O157:H7, Salmonella Enteritidis, and Listeria Monocytogenes”www.ncbi.nlm.nih.gov/pubmed/10473453 “Experimental Observations on the Antiseptic Action of Hypochlorous Acid and Its Application to Wound Treatment” www.ncbi.nlm.nih.gov/pmc/articles/PMC2302602/

SCIENTIFIC RESEARCH PUBLICATIONS

The    following    search    suggestions    will    provide    you    with    a myriad   of   resource   materials,   such   as   medical   publications, case   studies   and   news   articles   relative   to   hypochlorous   acid (HOCl).    We    have    systematically    researched    this    material over   the   years   to   realize   the   facts   and   further   our   knowledge and   understanding   of   this   wonderful   product.   As   a   result   of our   research,   we   are   encouraged   by   the   affirmation   of   the scientific   community   as   to   the   positive   effects   of   HOCl   on humans, animals, and the environment.
Furthering   the   development   of   Electro-Chemical   Activated (ECA)   Technology,   BRIOTECH   has   scientifically   engineered     a     process     to     mass-produce     hypochlorous     ( hī-′pə-klôr-′əs ) products    that    are    highly-effective.    The    ECA    formulations that    BRIOTECH    produces    are    superior    in    purity    and    can maintain   electrical   efficacy   for   up   to   two   years.   In   this   stable form,     these     electrically     active     HOCl     solutions     maintain efficacy   and   power   to   influence   many   biochemical   events   in human and animal tissues, and in microbes. Under    stringent    quality-control    procedures,    we    use    water (H2O)    and    salt    (NaCl)    to    create    a    specific    brine    solution,              and   then   pass   the   brine   through   a   proprietary,   electrolytic chamber.   The   finished   hypochlorous   acid   is   a   weak   acid;   it   is   a very   different   structure   from   the   strong   acid   generated   in the   stomach   (hydrochloric   acid)   that   works   to   start   digestive processes there. Throughout     the     world,     commercial     industries     such     as hospitality,   janitorial,   food   and   water   processing,   agricultural, animal   husbandry,   and   health   and   public   safety   have   adopted ECA   Technology   for   use,   eliminating   the   need   for   harmful, toxic chemicals.

HOW WE MAKE HOCL

- HOCl is a natural part of our internal defense system - Produced by white blood cells - Works to fight infection, control responses to      injury, and enhance healing - Part of the healthy response to injury and recover - HOCl consistently shows no adverse effects - Will not irritate or aggravate tissue damage at wound sites - There is no bubbling or tingling sensation, unlike many other    topically applied solutions - Soothing, steady control over the healing process that quickly      become evident - Safe for use on humans and animals
When   produced   outside   the   body,   HOCl   is   an   electrolyzed, antimicrobial,    biocide    solution    that    inactivates    pathogens such as bacteria, viruses, spores, and fungi.
HOCl O H Cl
- Only BRIO HOCL has been proven to eliminate the world’s    most dangerous and hardiest pathogen - More closely than any other HOCl on the market,    BRIOTECH mimics what is produced inside the body - Our formulations contain no active components other than    pure HOCl (unlike other HOCl producers) - Our HOCl is unmatched in safety, efficacy, and stability - BRIOTECH formulations are HOCl in its purest form - Our purity allows us to continually achieve ground-breaking    results - BRIOTECH’s scaling capacity sets the industry precedent for    production - BRIOTECH manufactures HOCl in an FDA-registered, GMP-    compliant facility - A commitment of eight years of scientific research and    testing in HOCl properties and production

HOW BRIOTECH HOCL IS UNIQUE

The    BRIOTECH    vision    has    always    been    about    what    HOCl can   do   for   the   good   of   man,   in   medicine,   and   healthcare,   and we’re    excited    to    lead    the    hypochlorous    acid    industry    with game-changing therapeutic and disinfection technologies. 1  
1 2 3 4 5
6